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Disadvantages of single sex classrooms

Random allocation in real trials is complex, but conceptually the process is like tossing a coin. The first reported clinical trial was conducted by James Lind in 1747 to identify treatment for scurvy. The first published RCT in medicine appeared disadvantages of single sex classrooms the 1948 paper entitled “Streptomycin treatment of pulmonary tuberculosis”, which described a Medical Research Council investigation.

By the late 20th century, RCTs were recognized as the standard method for “rational therapeutics” in medicine. As of 2004, more than 150,000 RCTs were in the Cochrane Library. RCTs, the ethics of RCTs have special considerations. The RCT method variations may also create cultural effects that have not been well understood. For example, patients with terminal illness may join trials in the hope of being cured, even when treatments are unlikely to be successful.

July 1, 2005 must be registered prior to consideration for publication in one of the 12 member journals of the committee. However, trial registration may still occur late or not at all. One way to classify RCTs is by study design. RCTs can be classified as “explanatory” or “pragmatic. Explanatory RCTs test efficacy in a research setting with highly selected participants and under highly controlled conditions. Another classification of RCTs categorizes them as “superiority trials”, “noninferiority trials”, and “equivalence trials”, which differ in methodology and reporting.