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Almost one in six people report about sex problems, such as low sex drive, while taking SSRIs. Men seem to more affected by SSRI antidepressants. Most of them report about erectile dysfunction and decline in sex desire. These antidepressants act by changing the levels of certain chemicals in the brain, like increasing the level of serotonin, which in its turn may negatively affect your sex drive. This happens due to the fact that these medications lower the production of some hormones, including testosterone, which is responsible for your libido. The study, published in the Journal of Clinical Endocrinology and Metabolism, showed that almost 95 percent of men and 68 percent of women reported about decreased sex drive.